Endocrine Abstracts

Introduction: Pancreatic neoplasms portray the 12th most prevalent neoplasm worldwide, determining a five-year survival of only 5 to 10% including all stages. Despite tumoral aggressiveness, the modified Appleby procedure can be performed in selected patients, representing a curable alternative in borderline-resectable or locally advanced pancreatic tumors’ treatment in the context of a multimodal practice. Objectives: This work aims to review the state of the art regardi...

Neuroprotection defines a set of homeostatic, self-repair mechanisms that probably evolved for the specially demanding conditions imposed by brain function. Among these, intercellular messengers such as the insulin-like growth factors (IGFs), that appeared very early during phylogeny, apparently play a prominent role despite their peripheral origin. In contrast to the heterogeneity seen in primitive organisms where at least 30 different IGF-like peptides are described, in mamm...

Introduction: Neonatal diabetes mellitus (NDM) is a rare disease diagnosed within the first months of life that is usually permanent in 50% of cases. Heterozygous mutations of KCNJ11 and ABCC8 genes encoding the two Kir6.2 and SUR1 subunits of the b-cell ATP-dependent potassium channel have been associated with NDM, which is characterized by a successful response to sulfonylureas.Case report: We present a 32-year-old woman diagnosed wit...

Background: At the Third International Workshop on asymptomatic primary hyperparathyroidism (PHPT), recent data on the disease were reviewed, but limited information of the PHPT management in Europe is available.Methods: We performed an online questionnaire survey in hospital endocrinology services to determine knowledge of current PHPT recommendations and its management in the clinical practice during 2009 Spain.Results: Ninety-ni...

Background: Catecholamine-secreting tumors that arise from chromaffin cells of the adrenal medulla and the sympathetic ganglia are respectively referred to as pheochromocytomas and paragangliomas. The classic triad of symptoms in patients with pheochromocytoma (PHEO)consists of episodic headache, sweating, and tachycardia. Approximately one-half have paroxysmal hypertension; the rest have either primary hypertension or normal blood pressure. Clinicians should always consider P...

Androgen receptor (AR) is an important target for inhibition by some endocrine disrupting chemicals. Some diphenyl compounds inhibit AR activity by binding to a hydrophobic surface binding site, BF3. A similar diphenyl structure is found in 4.4’ DDT and its breakdown product 4.4’ DDE. Previous results showed that DDT, DDE, and related compounds induced the release of bound dihydrotestosterone from the AR ligand binding domain with IC50 values ranging fro...

Estradiol (E2) may directly interact with growth factors stimulating cell proliferation and differentiation. Previously, we have demonstrated that E2 through membrane estrogen receptor α (mERα) modulates the lactotroph cell population which exhibit noticeable changes in the pituitary gland. The aim of this study was to analyze the mERα contribution on lactotroph cell proliferation in response to E2 and FGF-2 interaction evaluatin...

Introduction: Fine-needle biopsy(FNB) is an essential diagnostic tool in the evaluation of thyroid nodules, however, follicular neoplasm(FN) does not exclude malignancy. Some sonographic and cytological features have been described as being associated with increased risk of malignancy. The authors aimed to identify demographic, sonographic and cytologic features associated with malignancy in patients with a cytological diagnosis of FN.Methods: Descriptiv...

Introduction: Central diabetes insipidus (CDI) is characterized by a deficient secretion of anti-diuretic hormone (ADH), in which a large volume of hypotonic urine is eliminated. Pituitary metastatic disease is rare, accounting for 1% of all excised pituitary tumors and generally involves the posterior pituitary. Neoplasms that more often originate pituitary metastases are breast and lung cancer. Breast cancer (BC) is associated with pituitary secondary involvement in 5.3 to 2...

Objective: To evaluate the impact of a decision support system (DSS) based on artificial intelligence (AI) -KoiosDS- on ultrasound (US) image analysis and risk stratification in thyroid nodules. Material and methods Retrospective US study of all thyroid nodules with histologic (AP) result from June 2020 to December 2021. Diagnostic performance of US with ACR-TIRADS, by four endocrinologists and DSS, before and after the use of AI was evaluated.Results: A...